tag:blogger.com,1999:blog-10928736996033799942024-03-13T11:08:21.254-07:00From ME/CFS to XMRVLynn Bousquethttp://www.blogger.com/profile/17150638787869241440noreply@blogger.comBlogger1125tag:blogger.com,1999:blog-1092873699603379994.post-78818637115198390582011-01-21T09:42:00.000-08:002011-01-21T09:42:48.976-08:00XMRV and HopeSometimes I think of my life as having two parts. The full and active life I had before being diagnosed and the shadow life after the onset of ME/CFS.<br />
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Things have changed. Today, I am hopeful that there will be a third part to my life. The life where XMRV and related viruses are diagnosed and researched. The life where drug trials begin and remedies are found for this debilitating disease. A life that doesn't require that I rest up after every small activity. A life where I am strong and once again self sufficient. <br />
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Make no mistake about it, the time to put an end to this misunderstood, life-stealing disease is near. This blog is about the research that is already changing the way we view ME/CFS. We are just at the beginning. Much more research is needed. Here is the story of XMRV and hope.<br />
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<span class="text_exposed_show"> In 2009, Whittemore Peterson Institute scientists discovered a significant link between a newly-found retrovirus, xenotropic murine leukemia virus-related virus (XMRV), and the neuroimmune disease, ME/CFS. Their ground-breaking discovery was published in the world-renowned journal Science, on 8th October, 2010.<br />
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<a href="http://www.wpinstitute.org/xmrv/docs/wpi_pressrel_100809.pdf" rel="nofollow" target="_blank"><span>http://www.wpinstitute.org</span><wbr></wbr><span class="word_break"></span><span>/xmrv/docs/wpi_pressrel_10</span><wbr></wbr><span class="word_break"></span>0809.pdf</a><br />
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<a href="http://www.sciencemag.org/content/326/5952/585.abstract?keytype=ref&siteid=sci&ijkey=m3wzKT4yJqEyk" rel="nofollow" target="_blank"><span>http://www.sciencemag.org/</span><wbr></wbr><span class="word_break"></span><span>content/326/5952/585.abstr</span><wbr></wbr><span class="word_break"></span><span>act?keytype=ref&siteid=sci</span><wbr></wbr><span class="word_break"></span>&ijkey=m3wzKT4yJqEyk</a><br />
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This discovery brought renewed interest to the much-maligned disease and a flurry of research was conducted in order to confirm the link.<br />
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On August 23rd 2010, US government scientists validated the link, announcing they had found an association between a family of infectious murine leukaemia viruses and ME/CFS. They reported that 87% of those sampled carried at least one of the retroviruses, along with 7% (1 in 14) of the healthy controls.<br />
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<a href="http://www.rescindinc.org/fdanihpressconf.mp3" rel="nofollow" target="_blank"><span>http://www.rescindinc.org/</span><wbr></wbr><span class="word_break"></span>fdanihpressconf.mp3</a><br />
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<a href="http://www.cfscentral.com/2010/08/fdanihharvard-xmrv-study-same-thing.html" rel="nofollow" target="_blank"><span>http://www.cfscentral.com/</span><wbr></wbr><span class="word_break"></span><span>2010/08/fdanihharvard-xmrv</span><wbr></wbr><span class="word_break"></span>-study-same-thing.html</a><br />
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<a href="http://www.pnas.org/content/early/2010/08/16/1006901107.full.pdf+html" rel="nofollow" target="_blank"><span>http://www.pnas.org/conten</span><wbr></wbr><span class="word_break"></span><span>t/early/2010/08/16/1006901</span><wbr></wbr><span class="word_break"></span>107.full.pdf+html</a><br />
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<a href="http://www.pnas.org/content/early/2010/08/16/1007944107.full.pdf+html" rel="nofollow" target="_blank"><span>http://www.pnas.org/conten</span><wbr></wbr><span class="word_break"></span><span>t/early/2010/08/16/1007944</span><wbr></wbr><span class="word_break"></span>107.full.pdf+html</a><br />
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XMRV is similar to HIV, the retrovirus that causes AIDS.<br />
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Following the validation study several countries banned ME/CFS patients from giving blood. In many cases these bans are for life.<br />
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For more information on XMRV and the Whittemore Peterson Institute, please visit the following site: <a href="http://www.wpinstitute.org/" rel="nofollow" target="_blank"><span>http://www.wpinstitute.org</span><wbr></wbr><span class="word_break"></span>/</a><br />
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If you would like to donate a regular, small amount to help push this research on, then please consider participating in the COUNT ME IN campaign. For more details visit: <a href="http://www.facebook.com/note.php?note_id=160913563956987" rel="nofollow" target="_blank"><span>http://www.facebook.com/no</span><wbr></wbr><span class="word_break"></span><span>te.php?note_id=16091356395</span><wbr></wbr><span class="word_break"></span>6987</a><br />
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Here are some links you might want to use:- <br />
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Key Scientific Papers & Related:<br />
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Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome Science <a href="http://www.sciencemag.org/content/326/5952/585.abstract?keytype=ref&siteid=sci&ijkey=m3wzKT4yJqEyk" rel="nofollow" target="_blank"><span>http://www.sciencemag.org/</span><wbr></wbr><span class="word_break"></span><span>content/326/5952/585.abstr</span><wbr></wbr><span class="word_break"></span><span>act?keytype=ref&siteid=sci</span><wbr></wbr><span class="word_break"></span>&ijkey=m3wzKT4yJqEyk</a><br />
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Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donorshttp://<a href="http://www.pnas.org/content/early/2010/08/16/1006901107.abstract" rel="nofollow" target="_blank"><span>www.pnas.org/content/early</span><wbr></wbr><span class="word_break"></span><span>/2010/08/16/1006901107.abs</span><wbr></wbr><span class="word_break"></span>tract</a><br />
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Aug. 23, 2010 – Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors PNAS FDA Press Briefing <a href="http://www.wpinstitute.org/news/docs/FDAbriefing_082310.pdf" rel="nofollow" target="_blank"><span>http://www.wpinstitute.org</span><wbr></wbr><span class="word_break"></span><span>/news/docs/FDAbriefing_082</span><wbr></wbr><span class="word_break"></span>310.pdf</a><br />
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Blood Donor Bans:<br />
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<a href="http://mcwpa.org/in-the-news/blood-donor-bans/" rel="nofollow" target="_blank"><span>http://mcwpa.org/in-the-ne</span><wbr></wbr><span class="word_break"></span>ws/blood-donor-bans/</a><br />
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Pertinent News & Blog Reports:<br />
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A Big Splash From an Upstart Medical Center New York Times <a href="http://www.nytimes.com/2009/11/12/giving/12SICK.html" rel="nofollow" target="_blank"><span>http://www.nytimes.com/200</span><wbr></wbr><span class="word_break"></span>9/11/12/giving/12SICK.html</a><br />
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New Hope in Fatigue Fight Wall Street Journal <a href="http://online.wsj.com/article_email/SB10001424052748703846604575447744076968322-lMyQjAxMTAwMDIwMzEyNDMyWj.html" rel="nofollow" target="_blank"><span>http://online.wsj.com/arti</span><wbr></wbr><span class="word_break"></span><span>cle_email/SB10001424052748</span><wbr></wbr><span class="word_break"></span><span>70384660457544774407696832</span><wbr></wbr><span class="word_break"></span><span>2-lMyQjAxMTAwMDIwMzEyNDMyW</span><wbr></wbr><span class="word_break"></span>j.html</a><br />
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Viruses Found in Chronic Fatigue Syndrome Patients – National Institute of Health NIH Research Matters <a href="http://www.nih.gov/researchmatters/august2010/08302010chronicfatigue.htm" rel="nofollow" target="_blank"><span>http://www.nih.gov/researc</span><wbr></wbr><span class="word_break"></span><span>hmatters/august2010/083020</span><wbr></wbr><span class="word_break"></span>10chronicfatigue.htm</a><br />
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The Lingering Mystery of Chronic Fatigue Syndrome <a href="http://well.blogs.nytimes.com/2011/01/03/the-lingering-mystery-of-chronic-fatigue-syndrome/?ref=health" rel="nofollow" target="_blank"><span>http://well.blogs.nytimes.</span><wbr></wbr><span class="word_break"></span><span>com/2011/01/03/the-lingeri</span><wbr></wbr><span class="word_break"></span><span>ng-mystery-of-chronic-fati</span><wbr></wbr><span class="word_break"></span>gue-syndrome/?ref=health</a><br />
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Exhausted by Illness, and Doubts <a href="http://www.nytimes.com/2011/01/04/health/04fatigue.html" rel="nofollow" target="_blank"><span>http://www.nytimes.com/201</span><wbr></wbr><span class="word_break"></span><span>1/01/04/health/04fatigue.h</span><wbr></wbr><span class="word_break"></span>tml</a><br />
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XMRV and CFS – It’s not the end <a href="http://www.virology.ws/2010/12/22/xmrv-and-cfs-its-not-the-end/" rel="nofollow" target="_blank"><span>http://www.virology.ws/201</span><wbr></wbr><span class="word_break"></span><span>0/12/22/xmrv-and-cfs-its-n</span><wbr></wbr><span class="word_break"></span>ot-the-end/</a><br />
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Gearing Up for the Big Search for XMRV <a href="http://blogs.wsj.com/health/2010/11/17/gearing-up-for-the-big-search-for-xmrv/" rel="nofollow" target="_blank"><span>http://blogs.wsj.com/healt</span><wbr></wbr><span class="word_break"></span><span>h/2010/11/17/gearing-up-fo</span><wbr></wbr><span class="word_break"></span>r-the-big-search-for-xmrv/</a><br />
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Other XMRV Links:<br />
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Cleveland Clinic - 40% of patients with aggressive prostate cancer have XMRV <a href="http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.0020025" rel="nofollow" target="_blank"><span>http://www.plospathogens.o</span><wbr></wbr><span class="word_break"></span><span>rg/article/info%3Adoi%2F10</span><wbr></wbr><span class="word_break"></span><span>.1371%2Fjournal.ppat.00200</span><wbr></wbr><span class="word_break"></span>25</a><br />
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XMRV: Virological, immunological and clinical correlations in patients with chronic lymphocytic leukemia and mantle cell lymphoma <a href="http://www.wpinstitute.org/news/docs/Snyderman_XMRV.pdf" rel="nofollow" target="_blank"><span>http://www.wpinstitute.org</span><wbr></wbr><span class="word_break"></span><span>/news/docs/Snyderman_XMRV.</span><wbr></wbr><span class="word_break"></span>pdf</a><br />
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Xenotropic Murine Leukemia Virus–related Gammaretrovirus in Respiratory Tract <a href="http://www.cdc.gov/eid/content/16/6/1000.htm" rel="nofollow" target="_blank"><span>http://www.cdc.gov/eid/con</span><wbr></wbr><span class="word_break"></span>tent/16/6/1000.htm</a><br />
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COMPOSITIONS AND METHODS RELATING TO XMRV-RELATED DISEASES AND CONDITIONS <a href="http://www.wipo.int/pctdb/en/wo.jsp?WO=2010132886&IA=US2010035144&DISPLAY=DESC" rel="nofollow" target="_blank"><span>http://www.wipo.int/pctdb/</span><wbr></wbr><span class="word_break"></span><span>en/wo.jsp?WO=2010132886&IA</span><wbr></wbr><span class="word_break"></span>=US2010035144&DISPLAY=DESC</a><br />
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Of mice and men: on the origin of XMRV <a href="http://www.frontiersin.org/virology/10.3389/fmicb.2010.00147/abstract" rel="nofollow" target="_blank"><span>http://www.frontiersin.org</span><wbr></wbr><span class="word_break"></span><span>/virology/10.3389/fmicb.20</span><wbr></wbr><span class="word_break"></span>10.00147/abstract</a><br />
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XMRV retrovirus found in 62% of ME patients tested in Lillestrøm, Norway<br />
<a href="http://esme-eu.com/news/xmrv-retrovirus-found-in-62-of-me-patients-tested-in-lillestroem-norway-article440-7.html" rel="nofollow" target="_blank"><span>http://esme-eu.com/news/xm</span><wbr></wbr><span class="word_break"></span><span>rv-retrovirus-found-in-62-</span><wbr></wbr><span class="word_break"></span><span>of-me-patients-tested-in-l</span><wbr></wbr><span class="word_break"></span><span>illestroem-norway-article4</span><wbr></wbr><span class="word_break"></span>40-7.html</a><br />
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THE PREVALENCE OF XMRV IN HEALTHY BLOOD DONORS IN JAPAN <a href="http://www.diagnosesupport.com/health/index.php?option=com_content&view=article&id=305%3Athe-prevalence-of-xenotropic-murine-leukemia-virus-related-virus-in&catid=132%3Axmrv-research&Itemid=8" rel="nofollow" target="_blank"><span>http://www.diagnosesupport</span><wbr></wbr><span class="word_break"></span><span>.com/health/index.php?opti</span><wbr></wbr><span class="word_break"></span><span>on=com_content&view=articl</span><wbr></wbr><span class="word_break"></span><span>e&id=305%3Athe-prevalence-</span><wbr></wbr><span class="word_break"></span><span>of-xenotropic-murine-leuke</span><wbr></wbr><span class="word_break"></span><span>mia-virus-related-virus-in</span><wbr></wbr><span class="word_break"></span><span>&catid=132%3Axmrv-research</span><wbr></wbr><span class="word_break"></span>&Itemid=8</a><br />
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1st International Workshop on XMRV: Abstracts in Reviews in Antiviral Therapy & Infectious Diseases 2010_8. Abstracts <a href="http://regist2.virology-education.com/abstractbook/2010_8.pdf" rel="nofollow" target="_blank"><span>http://regist2.virology-ed</span><wbr></wbr><span class="word_break"></span><span>ucation.com/abstractbook/2</span><wbr></wbr><span class="word_break"></span>010_8.pdf</a><br />
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Distribution of xenotropic murine leukemia virus-related virus (XMRV) infection in chronic fatigue syndrome and prostate cancer Pubmed.gov <a href="http://www.ncbi.nlm.nih.gov/pubmed/20842203?dopt=Abstract" rel="nofollow" target="_blank"><span>http://www.ncbi.nlm.nih.go</span><wbr></wbr><span class="word_break"></span><span>v/pubmed/20842203?dopt=Abs</span><wbr></wbr><span class="word_break"></span>tract</a><br />
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A Third Pathogenic and Lymphotropic Human Retrovirus AIDS Review<br />
<a href="http://www.aidsreviews.com/files/2010_12_2_121-123.pdf" rel="nofollow" target="_blank"><span>http://www.aidsreviews.com</span><wbr></wbr><span class="word_break"></span><span>/files/2010_12_2_121-123.p</span><wbr></wbr><span class="word_break"></span>df</a></span>Lynn Bousquethttp://www.blogger.com/profile/17150638787869241440noreply@blogger.com11